- The National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and Office of Dietary Supplements (ODS) of the National Institutes of Health (NIH) invite research grant applications that will employ an integrative approach using state-of-the-art technologies to gain insight into the molecular and biochemical mechanisms of alcoholic and nonalcoholic fatty liver. This announcement addresses several areas considered to be high priority for liver disease research as delineated in the recently published Trans-NIH Action Plan for Liver Disease Research (http://liverplan.niddk.nih.gov), specifically in the area of fatty liver disease. The areas of focus include investigations of mechanisms by which alcohol and nonalcoholic physiologic processes: a) accelerate import of free fatty acids into hepatocytes; b) impair mitochondrial a-oxidation of fatty acids; c) impede the entry of fre!
e fatty acids into mitochondria; d) promote de novo fatty acid synthesis; e) promote esterification of free fatty acids into triglycerides; and f) disrupt export of triglycerides from hepatocytes. Research to develop non-invasive biomarkers for fatty liver using genomics, proteomics, and metabolomics, is also encouraged. Proposals investigating the modulating effects of dietary fatty acids, obesity, diabetes, insulin resistance, and components of the metabolic syndrome on alcoholic and nonalcoholic fatty liver are also encouraged. Understanding these mechanisms may help develop strategies for the prevention of accumulation of fat within the liver which may block or delay the progression of fatty liver to active hepatitis, fibrosis, and cirrhosis.
- Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.
- This PA will use the NIH R01, R21 and R03 mechanisms.
- Organizations that are eligible for this program include domestic non-profit organizations; public or private institutions, such as universities, colleges, hospitals, and laboratories; units of state and local governments; and eligible agencies of the Federal government.
- Eligible principal investigators include any individuals with the skills, knowledge, and resources necessary to carry out the proposed research.
- Applicants may submit more than one application, provided they are scientifically distinct.
- See Section IV.1 for application materials.
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Alcohol Research Programs
Digestive Diseases and Nutrition Research
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